In the United States today, over 16 million children live in poverty, 80%of low-income children are not reading at grade-level by the fourth grade, 35% of children live in single-parent households, and nearly 55%of young children are not in school. However, brain science has taught us that the foundations for success in both school and in life are established in the first five years of life. Yet the health, education, and social systems designed to serve young children are not delivering innovation or impact at scale. The systems are fragmented, dysfunctional, and are slow to adapt to the complex needs of people and communities.